Download A Biography of Paul Berg:The Recombinant DNA Controversy by Errol C Friedberg PDF

By Errol C Friedberg

With a Foreword via Sydney Brenner (Nobel laureate in body structure or drugs, 2002)

This biography info the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's existence from beginning, in 1926, to the current, with precise emphasis on his huge, immense medical contributions, together with being the 1st to increase expertise that ended in gene cloning technology. In 1980, Berg acquired a Nobel Prize in chemistry for this work.

In addition to his contributions within the examine laboratory, Berg orchestrated and oversaw a old assembly at Asilomar, California that established on a threatening controversy surrounding the notion through many of the damaging strength of recombinant DNA know-how. This assembly did a lot to stop this controversy and to install position the rules of recombinant DNA paintings, therefore placing fears to rest.

The recombinant DNA controversy used to be a ancient end result of the invention of gene cloning. significantly, it represented a paramount instance of clinical foresight and due diligence via the clinical neighborhood, instead of by way of regulatory entities within the usa and plenty of different nations. the last word reputation of gene/DNA cloning resulted in a brand new period of recent biology that flourishes to the present.

This e-book is aimed basically at scientists and people in education. The booklet strives to easily offer info for the final reader, yet isn't in particular adapted for a common examining audience.

While many books conceal the recombinant DNA controversy, none have satisfactorily addressed this ancient interval and are usually contradictory in regards to the many who is, where's, and why's concerned. also, the nice majority of those have been written by means of non-scientists. This biography of Paul Berg presents entry to various archived letters and records at Stanford college no longer formerly addressed, and to the chronology of occasions as recalled and documented by means of him, in addition to different key personalities, a lot of whom have been interviewed.

Contents:

  • Part I:
    • Growing Up in Brooklyn
    • The crucial Paul Berg
    • College — and global conflict II
    • Western Reserve University
    • Copenhagen
  • Part II:
    • Washington collage, St. Louis
    • Discovering move RNA
    • Stanford collage — and Its Refurbished division of Biochemistry
    • Transcription and Translation: New Directions
  • Part III:
    • Making Recombinant DNA — the 1st Faltering Steps
    • Making Recombinant DNA — an enormous Breakthrough
    • EcoRI limit Endonuclease — a tremendous Breakthrough
    • “Coincidence is the notice We Use after we cannot See the Levers and Pulleys”
    • Yet one other Stanford Contribution
  • Part IV:
    • An ancient assembly in Hawaii
    • The Recombinant DNA Controversy
    • A Momentous Gordon study Conference
    • Making Recombinant Molecules with Frog DNA
    • The Controversy Heats Up
    • Asilomar II
    • The Dissenters: a special element of View
    • The Aftermath
    • Legislative and Revisionist demanding situations to Recombinant DNA
    • Asilomar II — classes Learned
  • Part V:
    • The Nobel Prize in Chemistry
    • Commercializing the Technology
    • Life is going on
    • The “Retirement” Years
    • Public coverage matters — and different Interests
    • Personal Challenges

Readership: Researchers, graduate scholars, undergraduates in existence sciences, drugs and chemistry and lay public.

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